Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 3/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317984 | 0.93 | KDM4E (0.39) | SMN1; SMN2ACHEKDM4EMEN1MAPT | |
| SCHEMBL8316817 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2ACHEKDM4EMEN1MAPT | |
| SCHEMBL8643929 | 0.85 | ACHE (0.34) | SMN1; SMN2ACHEKDM4EMEN1MAPT | |
| SCHEMBL8316162 | 0.82 | MAPT (0.41) | SMN1; SMN2MEN1MAPTKMT2ALMNA | |
| SCHEMBL8555113 | 0.77 | KDM4E (0.40) | SMN1; SMN2ACHEKDM4EMEN1MAPT | |
| SCHEMBL8316058 | 0.76 | KMO (0.37) | ACHE | |
| SCHEMBL8649980 | 0.75 | GABRA2 (0.45) | SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL8558771 | 0.73 | KDM4E (0.40) | SMN1; SMN2ACHEKDM4EMEN1MAPT | |
| SCHEMBL8650346 | 0.71 | MAPT (0.39) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL7848182 | 0.70 | GRM5 (0.37) | KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772615-B1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE POULENC RORER SA (FR) | 1999-09-22 | — | — | EP | disclosed |
| US-5726175-A | MULTISTAGE PROCESS WITH CYCLIZATION AND AMINATION | RHONE-POULENC RORER S.A. (FR) | 1998-03-10 | — | — | US | disclosed |
| WO-1997025326-A1 | 2-SUBSTITUTED 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |
| EP-0772615-A1 | IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002544-A1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1996-02-01 | — | — | WO | disclosed |