Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853483 | 0.85 | MAPT (0.53) | SMN1; SMN2GFERKMT2AMAPTGAA | |
| SCHEMBL9853492 | 0.79 | SMN1; SMN2 (0.77) | SMN1; SMN2GFERKMT2ARECQLMAPT | |
| SCHEMBL6181273 | 0.78 | ESR1 (0.48) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL332626 | 0.74 | MAPT (0.71) | SMN1; SMN2KMT2AMGLLRECQLNR4A1 | |
| SCHEMBL29963430 | 0.74 | MAPT (0.71) | SMN1; SMN2KMT2AMGLLRECQLNR4A1 | |
| SCHEMBL28575134 | 0.74 | MGLL (0.44) | SMN1; SMN2GFERKMT2AMGLLRECQL | |
| SCHEMBL10847877 | 0.74 | SMN1; SMN2 (0.39) | SMN1; SMN2GFERKMT2AMGLLRAB9A | |
| SCHEMBL8317995 | 0.74 | RAB9A (0.46) | SMN1; SMN2GFERKMT2AMGLLMAPT | |
| SCHEMBL10847875 | 0.74 | SMN1; SMN2 (0.39) | SMN1; SMN2GFERKMT2AMGLLRAB9A | |
| SCHEMBL1339690 | 0.69 | GFER (0.64) | SMN1; SMN2GFERKMT2AMGLLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |