Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 11/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311345 | 0.86 | OPRL1 (0.43) | OPRL1OPRM1GRIA2 | |
| SCHEMBL904845 | 0.80 | OPRL1 (0.46) | OPRL1OPRM1CA12CA9CA2 | |
| SCHEMBL13158681 | 0.76 | PER2 (0.47) | OPRM1CA12CA9CA2ADRA1D | |
| SCHEMBL9537439 | 0.74 | PER2 (0.49) | CA12CA9CA2ADRA1DADRA1A | |
| SCHEMBL904818 | 0.70 | OPRL1 (0.48) | OPRL1OPRM1CA12CA9CA2 | |
| SCHEMBL11501224 | 0.69 | GAA (0.44) | CA12CA9ADRA1DADRA1AADRA1B | |
| SCHEMBL8313828 | 0.68 | GAA (0.44) | CA12CA9CA2GAAPRCP | |
| SCHEMBL8317764 | 0.68 | CA12 (0.38) | OPRM1CA12CA9CA2GAA | |
| SCHEMBL14575177 | 0.67 | CA12 (0.50) | CA12CA9CA2ADRA1DADRA1A | |
| SCHEMBL3285134 | 0.66 | SLC6A2 (0.45) | OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |