Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 11/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | PER2 | O15055 | 2/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316610 | 0.86 | OPRL1 (0.42) | OPRL1OPRM1GRIA2 | |
| SCHEMBL904845 | 0.81 | OPRL1 (0.46) | OPRL1OPRM1GRIA2 | |
| SCHEMBL904818 | 0.71 | OPRL1 (0.48) | OPRL1OPRM1GRIA2DRD4 | |
| SCHEMBL29602416 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL8314617 | 0.67 | LMNA (0.37) | — | |
| SCHEMBL3285134 | 0.67 | SLC6A2 (0.45) | OPRL1OPRM1 | |
| SCHEMBL6866920 | 0.64 | OPRL1 (0.67) | OPRL1OPRM1GRIA2 | |
| SCHEMBL8315746 | 0.63 | OPRL1 (0.32) | OPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL11099579 | 0.63 | OPRL1 (0.66) | OPRL1OPRM1GRIA2 | |
| SCHEMBL13158681 | 0.61 | PER2 (0.47) | OPRM1PER2CRY1CRY2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |