Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11503299 | 0.81 | TAAR1 (0.55) | ALDH1A1 | |
| SCHEMBL8422477 | 0.78 | MAPK1 (0.51) | ACHEKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11209706 | 0.77 | TSHR (0.48) | CYP1A2KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28374505 | 0.75 | TSHR (0.53) | ACHEMTNR1AMTNR1BKMT2ASMN1; SMN2 | |
| SCHEMBL576723 | 0.73 | FOLH1 (0.56) | HTTSMN1; SMN2 | |
| SCHEMBL4672371 | 0.73 | LOXL2 (0.62) | KMT2AALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL7989550 | 0.72 | CYP3A4 (0.54) | ACHEKMT2AMEN1 | |
| SCHEMBL2809012 | 0.72 | ENPP2 (0.50) | CYP1A2KMT2AALDH1A1IDH1 | |
| SCHEMBL21980935 | 0.71 | TSHR (0.53) | ACHEKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28055585 | 0.71 | ACHE (0.47) | ACHEMTNR1AMTNR1BKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367110-B1 | 1,4-diazepine derivative and its pharmaceutical use | EISAI CO LTD (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5482937-A | ANTIALLERGENS AND PLATELET ACTIVATING FACTOR FOR TREATMENT OF INFLAMMATION | EISAI CO., LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| US-5468740-A | Anti-platelet activating factor activity; antiallergens, antiasthmatics | EISAI CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| EP-0677524-A1 | Thieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives as PAF antagonists | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5438045-A | An 3-acetyl-6-phenyl-2,3,4,5-tetrahydro-8h-pyrido(4'3':4,5)-thieno(3,2 -f)(1,2,4)triazolo(4,3-a)(1,4)diazepine derivative; antiallergens; asthma; antiplatelet activating factor activity | EISAI CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5409909-A | Antiallergens | EISAI CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| US-5382579-A | Platelet activating factor antagonists; antiallergens; asthma | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| EP-0606103-A1 | Thieno 3.2-f 1,2,4 triazolo 4,3-a 1,4 -diazepine derivatives as PAF antagonists | Eisai Co., Ltd. (JP) | 1994-07-13 | — | — | EP | disclosed |
| US-5304553-A | Antiallergens; platelet activating factor inhibitor | EISAI CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| US-5221671-A | Antiallergens, bronchodilator agents | EISAI CO., LTD. (JP) | 1993-06-22 | — | — | US | disclosed |
| EP-0367110-A1 | 1,4-diazepine derivative and its pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-05-09 | — | — | EP | disclosed |