Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317651 | 0.88 | PIK3CD (0.39) | VHLALDH1A1MEN1KMT2ANLRP3 | |
| SCHEMBL8313957 | 0.88 | ALDH1A1 (0.33) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8316253 | 0.87 | CYP3A4 (0.33) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8317318 | 0.85 | POLB (0.35) | VHLCYP3A4MEN1KMT2ANLRP3 | |
| SCHEMBL8317047 | 0.84 | OPRK1 (0.35) | VHLCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL8316437 | 0.83 | MEN1 (0.33) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8314818 | 0.82 | KMT2A (0.37) | MEN1KMT2AMAPK1NLRP3POLB | |
| SCHEMBL8315579 | 0.82 | KMT2A (0.43) | VHLCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL8876139 | 0.81 | VHL (0.42) | VHLCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL9536573 | 0.80 | MEN1 (0.43) | MEN1KMT2AMAPK1POLBOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |