Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315579 | 0.89 | KMT2A (0.43) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8313747 | 0.88 | ALDH1A1 (0.35) | ALDH1A1MAPTSIRT1KMT2AMEN1 | |
| SCHEMBL8317543 | 0.88 | VHL (0.34) | PIK3CDALDH1A1KMT2AMEN1POLB | |
| SCHEMBL8318503 | 0.87 | ALDH1A1 (0.34) | ALDH1A1MAPTSIRT1KMT2AMEN1 | |
| SCHEMBL8317474 | 0.83 | KMT2A (0.35) | ALDH1A1MAPTSIRT1KMT2AMEN1 | |
| SCHEMBL8313446 | 0.82 | KMT2A (0.37) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8317047 | 0.82 | OPRK1 (0.35) | ALDH1A1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL8876496 | 0.81 | KMT2A (0.40) | PIK3CDALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8317318 | 0.81 | POLB (0.35) | PIK3CDKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL9383401 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |