Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321520 | 0.88 | CCR5 (0.46) | PTGER1HTTLMNA | |
| SCHEMBL8326795 | 0.86 | HTR1A (0.54) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9056586 | 0.85 | MEN1 (0.44) | — | |
| SCHEMBL8675704 | 0.74 | HDAC3 (0.44) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8324470 | 0.74 | PTGER1 (0.48) | PTGER1HTTFOLH1LMNA | |
| SCHEMBL8321988 | 0.73 | HTR1A (0.52) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8162190 | 0.73 | CCR5 (0.44) | PTGER1HTTLMNA | |
| SCHEMBL8324638 | 0.71 | MRGPRX4 (0.44) | PTGER1FOLH1 | |
| SCHEMBL19511860 | 0.71 | PTGER1 (0.49) | PTGER1HTT | |
| SCHEMBL4429436 | 0.71 | KDM4E (0.53) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |