Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.47 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321520 | 0.87 | CCR5 (0.46) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8326795 | 0.87 | HTR1A (0.54) | PTGER1HTTFOLH1ALDH1A1 | |
| SCHEMBL8319969 | 0.86 | USP28 (0.53) | PTGER1USP28USP25HTTCCR5 | |
| SCHEMBL9057884 | 0.85 | CCR5 (0.42) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8324638 | 0.85 | MRGPRX4 (0.44) | PTGER1FOLH1 | |
| SCHEMBL27405520 | 0.81 | USP28 (0.53) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8162287 | 0.80 | PTGER1 (0.48) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8321056 | 0.79 | FOLH1 (0.51) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8677627 | 0.77 | PTGER1 (0.49) | PTGER1CYP1A2USP28USP25HTT | |
| SCHEMBL8324067 | 0.77 | ABCB1 (0.53) | PTGER1CYP1A2FOLH1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |