Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.30 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989031 | 0.74 | NFE2L2 (0.37) | KCNN4GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6993867 | 0.71 | CES1 (0.43) | KCNN4GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL95707 | 0.70 | CES2 (0.42) | ALDH1A1 | |
| SCHEMBL6989492 | 0.66 | CES2 (0.37) | KCNN4GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15941518 | 0.65 | KIF11 (0.39) | KCNN4GAARAB9ASMN1; SMN2KIF11 | |
| SCHEMBL7705802 | 0.63 | CES2 (0.36) | ALDH1A1 | |
| SCHEMBL163604 | 0.62 | SLC22A12 (0.38) | GAASMN1; SMN2PTGS2ALDH1A1 | |
| SCHEMBL21201383 | 0.61 | ACHE (0.48) | GAAKMT2AALDH1A1 | |
| SCHEMBL7156428 | 0.61 | CES2 (0.39) | GAARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL535572 | 0.61 | TAAR1 (0.41) | GAASMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929533-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | Du Pont Pharmaceuticals Company (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014436-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-04-09 | — | — | WO | disclosed |