Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752842 | 0.77 | CA1 (0.57) | CA1CA2MAPTKIF11ALDH1A1 | |
| SCHEMBL8318021 | 0.72 | L3MBTL1 (0.57) | CA1CA2MEN1KMT2AMAPT | |
| SCHEMBL28704869 | 0.69 | LMNA (0.59) | MCL1HTTCA1CA2MEN1 | |
| SCHEMBL8318015 | 0.69 | MCL1 (0.46) | MCL1HTTIDH1HSD11B1POLB | |
| SCHEMBL11692985 | 0.67 | KEAP1 (0.46) | HTTMEN1KMT2AHSD11B1POLB | |
| SCHEMBL3882288 | 0.66 | PSIP1 (0.50) | HTTKMT2AMAPTL3MBTL1POLB | |
| SCHEMBL7194392 | 0.66 | KEAP1 (0.57) | HTTKMT2AL3MBTL1HSD11B1POLB | |
| SCHEMBL4250262 | 0.66 | PLCG1 (0.56) | HTTKMT2AL3MBTL1HSD11B1POLB | |
| SCHEMBL120756 | 0.66 | CYP1A2 (0.67) | MCL1MAPTIDH1CYP3A4CYP2C19 | |
| SCHEMBL23973993 | 0.65 | CA1 (0.58) | HTTCA1CA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966473-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038194-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1998-09-03 | — | — | WO | disclosed |