Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059786 | 0.88 | CHRM2 (0.46) | KMT2AMEN1L3MBTL1GBA2FKBP1A | |
| SCHEMBL9274408 | 0.88 | CHRM2 (0.46) | KMT2AMEN1L3MBTL1GBA2FKBP1A | |
| SCHEMBL8154541 | 0.79 | MEN1 (0.43) | KMT2AMEN1MAPK1HTTHTR7 | |
| SCHEMBL6668590 | 0.76 | CHRM2 (0.45) | KMT2AMEN1L3MBTL1FKBP1AKDM4E | |
| SCHEMBL932669 | 0.74 | RIPK1 (0.46) | HCRTR2 | |
| SCHEMBL2731646 | 0.73 | POLB (0.46) | KMT2AMEN1L3MBTL1GBA2FKBP1A | |
| SCHEMBL4202768 | 0.73 | POLB (0.46) | KMT2AMEN1L3MBTL1GBA2FKBP1A | |
| SCHEMBL31421713 | 0.73 | LMNA (0.47) | KMT2AMEN1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17674467 | 0.73 | GBA2 (0.44) | L3MBTL1GBA2ALDH1A1SMN1; SMN2CHRM2 | |
| SCHEMBL29747664 | 0.71 | GCK (0.40) | L3MBTL1FKBP1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906315-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049710-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |
| EP-0683767-A1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994019323-A1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-01 | — | — | WO | disclosed |