Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316500 | 0.84 | CA1 (0.50) | LMNAALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL4284172 | 0.82 | CA1 (0.52) | LMNAMAPK1ALDH1A1KMT2ARAB9A | |
| SCHEMBL2232322 | 0.82 | PARP1 (0.55) | MAPK1ALDH1A1KMT2ACES2CES1 | |
| SCHEMBL2887729 | 0.80 | CA5A (0.46) | LMNAMAPK1ALDH1A1KMT2ARAB9A | |
| SCHEMBL18605246 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1CES2CES1 | |
| SCHEMBL20630743 | 0.76 | LMNA (0.56) | LMNAMAPK1ALDH1A1KMT2ARAB9A | |
| SCHEMBL863160 | 0.76 | MAPK1 (0.56) | LMNAMAPK1ALDH1A1KMT2ARAB9A | |
| SCHEMBL16950659 | 0.76 | BACE1 (0.43) | LMNAALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL63193 | 0.75 | ALDH1A1 (0.59) | ALDH1A1CYP3A4CA1CA2CYP1A2 | |
| SCHEMBL6196892 | 0.74 | HPGD (0.59) | LMNAALDH1A1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| CN-1171788-A | Therapeutic agent for osteoporosis and triaza * compound | JAPAN TOBACCO INC (JP) | 1998-01-28 | — | — | CN | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |