Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324031 | 0.86 | BRD4 (0.47) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL9485553 | 0.82 | MMP1 (0.60) | HDAC1HDAC2LIMK2 | |
| SCHEMBL6870150 | 0.79 | MMP1 (0.53) | — | |
| SCHEMBL8324956 | 0.78 | HDAC1 (0.54) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL11050806 | 0.77 | CA1 (0.51) | BRD4ESR1LIMK2 | |
| SCHEMBL27706042 | 0.77 | ESR1 (0.57) | HDAC1HDAC6BRD4ESR1LIMK2 | |
| SCHEMBL17621 | 0.76 | HSD17B10 (0.62) | BRD4ESR1LIMK2 | |
| SCHEMBL8326744 | 0.75 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| Hydrochloric Acid SCHEMBL233781 | 0.75 | HSD17B10 (0.60) | BRD4ESR1LIMK2 | |
| Iodide SCHEMBL28519464 | 0.75 | HSD17B10 (0.60) | BRD4ESR1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |