Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.49 |
| ▸ | METAP1 | P53582 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319741 | 0.75 | MAPT (0.45) | ACHEMETAP1MAPTMAPK1ATM | |
| SCHEMBL15670682 | 0.72 | ACHE (0.53) | ACHEMETAP1MAPTCYP19A1TSHR | |
| SCHEMBL10947753 | 0.72 | ACHE (0.49) | ACHEMETAP1MAPTCYP19A1TSHR | |
| SCHEMBL10947764 | 0.72 | ACHE (0.49) | ACHEMETAP1MAPTCYP19A1TSHR | |
| SCHEMBL16795631 | 0.72 | ACHE (0.51) | ACHEMETAP1CYP19A1TSHR | |
| SCHEMBL8319737 | 0.72 | ACHE (0.45) | ACHEMETAP1MAPTCYP19A1MAPK1 | |
| SCHEMBL5667503 | 0.71 | ACHE (0.51) | ACHEMETAP1CYP19A1TSHRNPC1 | |
| SCHEMBL11859079 | 0.71 | ACHE (0.44) | ACHEMETAP1CYP19A1TSHRNPC1 | |
| SCHEMBL8045729 | 0.70 | ACHE (0.50) | ACHEMETAP1MAPTCYP19A1TSHR | |
| Ethylene SCHEMBL9316053 | 0.70 | ACHE (0.46) | ACHEMETAP1MAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752993-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026351-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-10-05 | — | — | WO | disclosed |