Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322376 | 0.79 | SMN1; SMN2 (0.49) | GABRA1GABRA2NPC1LMNARAB9A | |
| SCHEMBL8468606 | 0.78 | NPC1 (0.40) | GABRA1GABRA2TP53POLBRXFP1 | |
| Water SCHEMBL8323447 | 0.67 | LMNA (0.37) | TP53RXFP1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL8321754 | 0.66 | KDM4E (0.41) | TP53POLBLMNASMN1; SMN2KDM4E | |
| SCHEMBL8320446 | 0.66 | NPC1 (0.49) | GABRA1GABRA2NPC1LMNARAB9A | |
| SCHEMBL8466300 | 0.66 | GAA (0.43) | TP53POLBNPC1LMNARAB9A | |
| SCHEMBL8466029 | 0.64 | SCN9A (0.32) | NPC1LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8329043 | 0.63 | TEAD1 (0.39) | TP53SMN1; SMN2 | |
| SCHEMBL8322673 | 0.63 | AURKA (0.36) | TP53POLBNPC1LMNARAB9A | |
| SCHEMBL8523787 | 0.63 | NPC1 (0.52) | GABRA1GABRA2NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |