Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.31 |
| ▸ | PGR | P06401 | 3/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090728 | 0.83 | IMPDH2 (0.39) | IMPDH2KDM4EMEN1LMNAPOLB | |
| SCHEMBL6092231 | 0.69 | KIF11 (0.34) | IMPDH2KDM4EMEN1LMNAPOLB | |
| SCHEMBL27174846 | 0.69 | IMPDH2 (0.46) | IMPDH2KDM4EMEN1LMNAPOLB | |
| SCHEMBL9504874 | 0.67 | TSHR (0.62) | LMNAMAPTTSHR | |
| SCHEMBL15591975 | 0.66 | KIF11 (0.52) | KDM4ETSHRNR3C1PGRNR3C2 | |
| SCHEMBL7089054 | 0.66 | REN (0.50) | IMPDH2KDM4EPOLBMAPTTSHR | |
| SCHEMBL8331367 | 0.66 | NR3C1 (0.66) | IMPDH2CLK1CDK5CDK5R1NR3C1 | |
| SCHEMBL6089244 | 0.66 | NR3C1 (0.39) | IMPDH2KDM4EMEN1LMNAPOLB | |
| SCHEMBL28995681 | 0.66 | KDM4E (0.53) | IMPDH2KDM4EMEN1LMNAPOLB | |
| SCHEMBL6091711 | 0.65 | KIF11 (0.39) | IMPDH2KDM4EMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |