Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.75 |
| ▸ | EGFR | P00533 | 15/20 | 0.75 |
| ▸ | ABL1 | P00519 | 12/20 | 0.75 |
| ▸ | ABL2 | P42684 | 11/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 5/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | TEK | Q02763 | 4/20 | 0.62 |
| ▸ | LYN | P07948 | 3/20 | 0.62 |
| ▸ | FYN | P06241 | 2/20 | 0.62 |
| ▸ | CSK | P41240 | 2/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | RGS12 | O14924 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320799 | 0.86 | SRC (0.81) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL132510 | 0.86 | SRC (1.00) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL23847603 | 0.85 | LCK (0.76) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL30893895 | 0.85 | LCK (0.76) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL5936173 | 0.85 | SRC (0.97) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL13020153 | 0.83 | SRC (0.58) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL20351637 | 0.83 | SRC (0.65) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7020883 | 0.82 | EGFR (0.67) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL24651203 | 0.82 | ABL1 (0.49) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7023713 | 0.81 | SRC (0.72) | SRCEGFRABL1ABL2RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO 2,3-D]PYRIDINES AND THEIR USE | Novartis AG (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034895-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO[2,3-D]PYRIDINES AND THEIR USE | NOVARTIS AG (CH) | 1997-09-25 | — | — | WO | disclosed |