Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319315 | 0.90 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL8320614 | 0.76 | CYSLTR1 (0.36) | CYSLTR1GPBAR1 | |
| SCHEMBL8019618 | 0.72 | MAOA (0.62) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL8140420 | 0.71 | PDE10A (0.49) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL10544473 | 0.71 | CYSLTR1 (0.84) | CYSLTR1GPBAR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL8317460 | 0.70 | CYSLTR1 (0.74) | CYSLTR1GPBAR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL8801873 | 0.70 | MAOB (0.58) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8801952 | 0.70 | MAOA (0.62) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL8503497 | 0.69 | CYSLTR1 (0.66) | CYSLTR1GPBAR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL27410711 | 0.69 | FFAR1 (0.67) | CYSLTR1GPBAR1FFAR1AKR1B1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885987-A | ANTIHISTAMINE AGENT FOR TREATING ASTHMA, ANTILEUKOTRIENE AGENT, ANTIALLERGENS | KOWA CO., LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5756518-A | EXHIBITS ANTILEUKOTRIENIC ACTION AND ANTIHISTAMINIC ACTION; IS USEFUL IN TREATMENT OF ASTHMA | KOWA CO., LTD. (JP) | 1998-05-26 | — | — | US | disclosed |