Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330362 | 0.89 | HTR2A (0.38) | HTR2AHTR2COPRM1MEN1KMT2A | |
| SCHEMBL8328986 | 0.83 | HTR2A (0.42) | HTR2AHTR2COPRM1POLBMEN1 | |
| SCHEMBL8329435 | 0.76 | HTR2A (0.39) | HTR2AHTR2COPRM1MEN1KMT2A | |
| SCHEMBL8326874 | 0.76 | HTR2A (0.42) | HTR2AHTR2CALDH1A1HPGD | |
| SCHEMBL8326463 | 0.75 | ALDH1A1 (0.40) | OPRM1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8327585 | 0.73 | OPRM1 (0.40) | OPRM1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8322854 | 0.72 | ALDH1A1 (0.36) | OPRM1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3156042 | 0.71 | HTR2A (0.46) | HTR2AHTR2COPRM1HPGDSMN1; SMN2 | |
| SCHEMBL21028327 | 0.71 | HTR2A (0.42) | HTR2AHTR2CMEN1KMT2A | |
| SCHEMBL8656153 | 0.70 | HTR2A (0.41) | HTR2AHTR2CMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |