Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327585 | 0.89 | OPRM1 (0.40) | ALDH1A1KDM4ERAB9AOPRM1NPSR1 | |
| SCHEMBL8329097 | 0.77 | OPRM1 (0.37) | ALDH1A1KDM4EOPRM1KMT2AL3MBTL1 | |
| SCHEMBL8322854 | 0.75 | ALDH1A1 (0.36) | ALDH1A1KDM4ERAB9AOPRM1KMT2A | |
| SCHEMBL8320925 | 0.75 | HTR2A (0.42) | ALDH1A1KDM4EOPRM1KMT2AGAA | |
| SCHEMBL8330362 | 0.74 | HTR2A (0.38) | ALDH1A1KDM4ERAB9AOPRM1KMT2A | |
| SCHEMBL8327931 | 0.74 | NR1H2 (0.35) | ALDH1A1OPRM1KMT2AL3MBTL1MEN1 | |
| SCHEMBL8328986 | 0.70 | HTR2A (0.42) | ALDH1A1KDM4ERAB9AOPRM1KMT2A | |
| SCHEMBL8655802 | 0.68 | MAPT (0.44) | ALDH1A1KDM4ERAB9AKMT2AGAA | |
| SCHEMBL7737588 | 0.68 | ALDH1A1 (0.44) | ALDH1A1KDM4EOPRM1NPSR1KMT2A | |
| SCHEMBL30954226 | 0.67 | ALDH1A1 (0.39) | ALDH1A1KDM4ENPSR1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |