Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328986 | 0.89 | HTR2A (0.42) | HTR2AHTR2CALDH1A1OPRM1MEN1 | |
| SCHEMBL8320925 | 0.89 | HTR2A (0.42) | HTR2AHTR2CALDH1A1OPRM1MEN1 | |
| SCHEMBL3156042 | 0.75 | HTR2A (0.46) | HTR2AHTR2COPRM1HPGD | |
| SCHEMBL8326463 | 0.74 | ALDH1A1 (0.40) | ALDH1A1OPRM1MEN1KMT2ANOD2 | |
| SCHEMBL8322854 | 0.73 | ALDH1A1 (0.36) | ALDH1A1OPRM1MEN1KMT2ANOD2 | |
| SCHEMBL8325800 | 0.73 | ALDH1A1 (0.39) | HTR2AHTR2CALDH1A1MEN1KMT2A | |
| SCHEMBL22904560 | 0.72 | BRD4 (0.48) | OPRM1MEN1KMT2ATSHRGAA | |
| SCHEMBL8327585 | 0.70 | OPRM1 (0.40) | ALDH1A1OPRM1MEN1KMT2ANOD2 | |
| SCHEMBL8329435 | 0.69 | HTR2A (0.39) | HTR2AHTR2CALDH1A1OPRM1MEN1 | |
| SCHEMBL8322862 | 0.68 | MEN1 (0.36) | HTR2AHTR2COPRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |