Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 14/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321994 | 1.00 | HDAC4 (0.44) | HDAC4HDAC8GPR35SLC9A1PPARG | |
| SCHEMBL8113013 | 0.96 | GPR35 (0.45) | HDAC4HDAC8GPR35PPARGKCNH2 | |
| SCHEMBL8113007 | 0.96 | GPR35 (0.45) | HDAC4HDAC8GPR35PPARGKCNH2 | |
| Hydrochloric Acid SCHEMBL8318758 | 0.95 | GPR35 (0.45) | HDAC4HDAC8GPR35PPARGKCNH2 | |
| SCHEMBL8322665 | 0.94 | HPGD (0.45) | HDAC4HDAC8GPR35PPARGKCNH2 | |
| SCHEMBL8322667 | 0.94 | HPGD (0.45) | HDAC4HDAC8GPR35PPARGKCNH2 | |
| SCHEMBL10365844 | 0.87 | GPR35 (0.56) | HDAC4HDAC8GPR35PPARGHPGD | |
| SCHEMBL10365841 | 0.87 | GPR35 (0.56) | HDAC4HDAC8GPR35PPARGHPGD | |
| SCHEMBL10365846 | 0.80 | PPARG (0.46) | HDAC4HDAC8GPR35PPARGHPGD | |
| SCHEMBL10365647 | 0.75 | GPR35 (0.60) | HDAC4HDAC8GPR35PPARGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955481-A | Pyridine type thiazolidines | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |