Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.60 |
| ▸ | EDNRB | P24530 | 14/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322002 | 0.81 | EDNRA (0.46) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL8326459 | 0.80 | EDNRB (0.41) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL7330283 | 0.77 | DHPS (0.46) | EDNRAEDNRB | |
| SCHEMBL7329858 | 0.76 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7327165 | 0.76 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8322432 | 0.75 | LMNA (0.41) | EDNRAMEN1POLBKMT2A | |
| SCHEMBL8322960 | 0.75 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL7330749 | 0.74 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL7333240 | 0.74 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7696685 | 0.72 | EDNRA (0.57) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | claimed |
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |