Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322926 | 0.83 | IDO1 (0.52) | TACR1CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL8327108 | 0.81 | NFE2L2 (0.44) | GRIK1GRIK2ALDH1A1TSHR | |
| SCHEMBL8329048 | 0.81 | NPC1 (0.46) | CACNA1CSLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL8322049 | 0.78 | TACR1 (0.41) | TACR1GRIK1GRIK2 | |
| SCHEMBL8321285 | 0.74 | TRPA1 (0.49) | TACR1GRIK1GRIK2ALDH1A1ACP3 | |
| SCHEMBL265124 | 0.73 | PDE2A (0.39) | TACR1CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL8326846 | 0.72 | RELA (0.46) | SLC6A2SLC6A4SLC6A3KCNH2GRIK1 | |
| SCHEMBL3738246 | 0.72 | TACR1 (0.50) | TACR1CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL2010847 | 0.71 | ACP3 (0.55) | TACR1CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL28408423 | 0.71 | DPP4 (0.61) | TACR1CACNA1CCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |