Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324977 | 0.83 | IDO1 (0.49) | NPC1RAB9AALDH1A1ACP3MEN1 | |
| SCHEMBL14910878 | 0.82 | TAAR1 (0.50) | HTR2ATAAR1RIPK1 | |
| SCHEMBL8325622 | 0.81 | NFE2L2 (0.44) | NPC1TSHRALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL8322780 | 0.81 | TACR1 (0.46) | NPC1RAB9ATSHRALDH1A1ACP3 | |
| SCHEMBL8325764 | 0.80 | TAAR1 (0.44) | TSHRLMNAACHETAAR1SMN1; SMN2 | |
| SCHEMBL8325507 | 0.75 | TRPA1 (0.50) | ALDH1A1ACP3MEN1KMT2ATAAR1 | |
| SCHEMBL28724553 | 0.73 | PDE2A (0.42) | TSHRALDH1A1ACP3CYP2D6CYP2C19 | |
| SCHEMBL28724552 | 0.73 | PDE2A (0.42) | TSHRALDH1A1ACP3CYP2D6CYP2C19 | |
| SCHEMBL17071860 | 0.71 | ACP3 (0.55) | NPC1RAB9ATSHRALDH1A1ACP3 | |
| SCHEMBL8326251 | 0.71 | NPC1 (0.59) | NPC1RAB9ATSHRALDH1A1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |