Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | TDO2 | P48775 | 2/20 | 0.52 |
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322780 | 0.83 | TACR1 (0.46) | IDO1TDO2TACR1CACNA1FCACNA1D | |
| SCHEMBL8324977 | 0.82 | IDO1 (0.49) | IDO1TDO2PNMTHTR2AHTR2C | |
| SCHEMBL8321946 | 0.80 | NFE2L2 (0.49) | IDO1TDO2NFE2L2NPC1RAB9A | |
| SCHEMBL8323194 | 0.78 | MAOA (0.50) | TACR1NPC1MAPT | |
| SCHEMBL8324064 | 0.77 | SCN4A (0.44) | IDO1TDO2TACR1NPC1RAB9A | |
| SCHEMBL8326302 | 0.77 | HTR2A (0.41) | HTR2A | |
| SCHEMBL8324378 | 0.77 | SCN4A (0.44) | TACR1NPC1 | |
| SCHEMBL27796912 | 0.74 | NFE2L2 (0.50) | IDO1TDO2PNMTHTR2AHTR2C | |
| SCHEMBL13358903 | 0.74 | PNMT (0.51) | IDO1TDO2TACR1PNMTHTR2A | |
| SCHEMBL266165 | 0.74 | PNMT (0.51) | IDO1TDO2TACR1CACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |