Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.65 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337792 | 0.79 | ITGB3 (0.71) | ITGB3ITGA2BALOX15KDM4EALDH1A1 | |
| SCHEMBL6839445 | 0.79 | ITGB3 (1.00) | ITGB3ITGA2BALOX15MEN1KMT2A | |
| SCHEMBL7344150 | 0.78 | ITGB3 (0.69) | ITGB3ITGA2BALOX15 | |
| SCHEMBL27418902 | 0.77 | ITGB3 (0.68) | ITGB3ITGA2BALOX15KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8431411 | 0.77 | ALOX15 (0.98) | ITGB3ITGA2BALOX15MEN1KMT2A | |
| SCHEMBL7344590 | 0.74 | ITGB3 (0.71) | ITGB3ITGA2BALOX15KMT2AMAPT | |
| SCHEMBL7345703 | 0.74 | ITGB3 (0.71) | ITGB3ITGA2BALOX15 | |
| Trifluoroacetic Acid SCHEMBL7347536 | 0.74 | ITGB3 (0.63) | ITGB3ITGA2BALOX15KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7334802 | 0.73 | ITGB3 (0.87) | ITGB3ITGA2BALOX15MEN1KMT2A | |
| SCHEMBL29683649 | 0.72 | KDM4E (0.48) | ALOX15KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |