Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093738 | 0.85 | MIF (0.43) | KDM4EALDH1A1MIFTAAR1 | |
| SCHEMBL8324324 | 0.82 | ACP3 (0.46) | TP53MAPTALOX12TDP1TAAR1 | |
| SCHEMBL8324964 | 0.82 | KDM4E (0.38) | HDAC4HDAC8KDM4EMDM4ALDH1A1 | |
| SCHEMBL8325683 | 0.82 | CYP3A4 (0.38) | HDAC4HDAC8KDM4EMDM4ALDH1A1 | |
| SCHEMBL8319057 | 0.81 | ACP3 (0.45) | ALDH1A1CYP3A4MAPTHPGDALOX15 | |
| SCHEMBL8323859 | 0.81 | MAOA (0.41) | KDM4EALDH1A1CA1CA2CYP3A4 | |
| SCHEMBL8330722 | 0.81 | IDO1 (0.46) | HDAC4KDM4E | |
| Benzene SCHEMBL7084450 | 0.80 | HDAC4 (0.54) | HDAC4HDAC8KDM4EMDM4ALDH1A1 | |
| Hydrogen Peroxide SCHEMBL1877668 | 0.78 | HDAC4 (0.58) | HDAC4HDAC8KDM4EMDM4ALDH1A1 | |
| Hydrogen Peroxide SCHEMBL315899 | 0.78 | HDAC4 (0.58) | HDAC4HDAC8KDM4EMDM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |