Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324389 | 0.85 | HTR7 (0.58) | HTR7HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL5675706 | 0.82 | HTR7 (0.64) | HTR7HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3305551 | 0.82 | TAS2R14 (0.44) | HTR7TAS2R14KDM4EALDH1A1 | |
| SCHEMBL3162853 | 0.81 | CA2 (0.45) | TAS2R14LMNAKDM4EALDH1A1 | |
| SCHEMBL23630646 | 0.79 | HRH3 (0.46) | HTR7 | |
| SCHEMBL31207322 | 0.79 | HRH3 (0.46) | HTR7 | |
| SCHEMBL2432106 | 0.79 | PTGS2 (0.52) | KDM4EALDH1A1 | |
| SCHEMBL23972532 | 0.78 | HRH3 (0.50) | HTR7HTR2ALMNAALDH1A1 | |
| SCHEMBL11648537 | 0.78 | TAAR1 (0.61) | HTR7LMNAALDH1A1CYP3A4 | |
| SCHEMBL1961585 | 0.78 | ALDH1A1 (0.67) | HTR7HTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |