Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.53 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057884 | 0.88 | CCR5 (0.42) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8324470 | 0.86 | PTGER1 (0.48) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8321520 | 0.81 | CCR5 (0.46) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8676639 | 0.78 | USP28 (0.52) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8326795 | 0.74 | HTR1A (0.54) | HTTALDH1A1PTGER1 | |
| SCHEMBL16294248 | 0.73 | USP28 (0.69) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8324638 | 0.72 | MRGPRX4 (0.44) | PTGER1 | |
| SCHEMBL8680267 | 0.72 | LRRK2 (0.49) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL8321690 | 0.72 | CCR5 (0.40) | USP28USP25HTTALDH1A1CCR5 | |
| SCHEMBL27405520 | 0.71 | USP28 (0.53) | USP28USP25HTTALDH1A1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |