Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319163 | 0.82 | ALDH1A1 (0.39) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8325988 | 0.81 | PDE4D (0.35) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8320953 | 0.81 | ALDH1A1 (0.39) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8324499 | 0.81 | CNR2 (0.35) | PDE4APDE4DPDE4BPDE4CCYP19A1 | |
| SCHEMBL8324241 | 0.79 | PDE4D (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8323847 | 0.79 | TSHR (0.37) | POLB | |
| SCHEMBL8324231 | 0.79 | ALDH1A1 (0.43) | — | |
| SCHEMBL8325518 | 0.71 | MAPT (0.38) | PDE4DPDE4B | |
| SCHEMBL6921360 | 0.68 | ALDH1A1 (0.43) | POLB | |
| SCHEMBL73469 | 0.68 | PDE4A (0.41) | PDE4APDE4DPDE4BPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |