Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356980 | 0.92 | MEN1 (0.67) | TAS1R3TAS1R1MEN1KMT2AROCK2 | |
| SCHEMBL11755664 | 0.88 | MEN1 (0.70) | TAS1R3TAS1R1MEN1KMT2ARAB9A | |
| SCHEMBL930908 | 0.86 | ROCK2 (0.76) | MEN1KMT2AROCK2RAB9AHTT | |
| SCHEMBL14340547 | 0.84 | TAS1R3 (0.64) | TAS1R3TAS1R1MEN1KMT2AROCK2 | |
| SCHEMBL17758484 | 0.84 | ROCK2 (0.61) | MEN1KMT2AROCK2RAB9AHTT | |
| SCHEMBL12988882 | 0.83 | L3MBTL1 (0.57) | KMT2ASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL26446035 | 0.82 | TAS1R3 (0.49) | TAS1R3TAS1R1MEN1KMT2AROCK2 | |
| SCHEMBL8324748 | 0.82 | TAS1R3 (0.64) | TAS1R3TAS1R1MEN1KMT2AROCK2 | |
| SCHEMBL6582492 | 0.81 | HTT (0.65) | TAS1R3TAS1R1MEN1KMT2ARAB9A | |
| SCHEMBL30622701 | 0.81 | HTT (0.65) | TAS1R3TAS1R1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |