Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523766 | 0.87 | KDM4E (0.39) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL8604054 | 0.86 | GAA (0.49) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL8320581 | 0.84 | NPSR1 (0.48) | RAB9ANPSR1ADORA3LMNAKDM4E | |
| SCHEMBL8523787 | 0.73 | NPC1 (0.52) | GAASMN1; SMN2RAB9ANPC1ADORA3 | |
| Water SCHEMBL8466755 | 0.69 | NPC1 (0.42) | GAASMN1; SMN2RAB9ANPC1ADORA3 | |
| SCHEMBL8462289 | 0.68 | MAPT (0.47) | RAB9ANPSR1ADORA3KDM4ESYK | |
| SCHEMBL8321791 | 0.68 | L3MBTL1 (0.39) | GAARAB9ANPSR1ADORA3KDM4E | |
| SCHEMBL8322376 | 0.68 | SMN1; SMN2 (0.49) | GAASMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL4060439 | 0.67 | GAA (0.68) | GAASMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL8460257 | 0.67 | NPSR1 (0.46) | RAB9ANPSR1ADORA3LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | disclosed |