Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324852 | 0.87 | GAA (0.53) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL8320581 | 0.81 | NPSR1 (0.48) | KDM4ERAB9AALDH1A1LMNATRPV4 | |
| SCHEMBL8523477 | 0.77 | PBK (0.39) | RAB9ASMN1; SMN2NPC1DHODHALDH1A1 | |
| SCHEMBL4057758 | 0.76 | RAB9A (0.51) | RAB9AGAASMN1; SMN2NPC1DHODH | |
| SCHEMBL8604054 | 0.75 | GAA (0.49) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL4059604 | 0.70 | RAB9A (0.55) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| Water SCHEMBL8326247 | 0.68 | ESR2 (0.33) | GAASMN1; SMN2DHODHALDH1A1LMNA | |
| SCHEMBL8321791 | 0.67 | L3MBTL1 (0.39) | KDM4ERAB9AGAAALDH1A1TRPV4 | |
| SCHEMBL8462289 | 0.67 | MAPT (0.47) | KDM4ERAB9ATRPV4MAPTL3MBTL1 | |
| SCHEMBL8460257 | 0.65 | NPSR1 (0.46) | KDM4ERAB9AALDH1A1LMNANPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |