Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305023 | 0.81 | ALDH1A1 (0.44) | RAB9ATSHRSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8307013 | 0.81 | ALDH1A1 (0.45) | POLBTSHRSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8326272 | 0.80 | CA12 (0.41) | RAB9ATSHRHSD17B10MEN1KMT2A | |
| SCHEMBL9070589 | 0.76 | CA12 (0.43) | POLBSMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL8546281 | 0.75 | MAPT (0.58) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8554638 | 0.74 | ALDH1A1 (0.40) | NPC1RAB9APOLBTSHRSMN1; SMN2 | |
| SCHEMBL8305025 | 0.73 | ALDH1A1 (0.41) | NPC1RAB9APOLBTSHRSMN1; SMN2 | |
| SCHEMBL8307015 | 0.73 | KDM4E (0.46) | NPC1RAB9APOLBTSHRSMN1; SMN2 | |
| SCHEMBL9075776 | 0.72 | ALDH1A1 (0.48) | NPC1RAB9APOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL16547892 | 0.68 | MAPT (0.57) | NPC1RAB9APOLBTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |