Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.58 |
| ▸ | CNR2 | P34972 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549320 | 0.78 | MAPT (0.46) | MAPTSMN1; SMN2CYP3A4CNR1CNR2 | |
| SCHEMBL8324883 | 0.75 | NPC1 (0.48) | MAPTSMN1; SMN2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL5225465 | 0.74 | SLC22A12 (0.52) | MAPTSMN1; SMN2CYP3A4CNR1CNR2 | |
| SCHEMBL3736014 | 0.73 | CNR2 (1.00) | MAPTSMN1; SMN2CYP3A4CNR1CNR2 | |
| SCHEMBL8544863 | 0.73 | KDM4E (0.58) | MAPTSMN1; SMN2CASP1CASP7KDM4E | |
| SCHEMBL8550683 | 0.71 | DGAT2 (0.41) | MAPTSMN1; SMN2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL7123280 | 0.71 | CNR2 (0.90) | MAPTSMN1; SMN2CYP3A4CNR1CNR2 | |
| SCHEMBL8543822 | 0.70 | CASP1 (0.52) | MAPTSMN1; SMN2CASP1CASP7KDM4E | |
| SCHEMBL4437800 | 0.70 | ALDH1A1 (0.52) | MAPTSMN1; SMN2CASP1CASP7KDM4E | |
| SCHEMBL16541126 | 0.70 | MAPT (0.61) | MAPTSMN1; SMN2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504213-A | ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | claimed |
| EP-0623607-B1 | Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives | BAYER AG (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5504213-A | ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |
| EP-0623607-A1 | Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives | BAYER AG (DE) | 1994-11-09 | — | — | EP | disclosed |