Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319605 | 0.92 | MTNR1A (0.58) | MTNR1AMTNR1BABCB1HTR1ADRD2 | |
| SCHEMBL8321603 | 0.88 | PTGER1 (0.54) | MTNR1AMTNR1BABCB1HTR1ADRD2 | |
| SCHEMBL8319729 | 0.88 | ABCB1 (0.56) | ABCB1HTR1ADRD2MAOB | |
| SCHEMBL8322935 | 0.88 | CCR5 (0.49) | — | |
| SCHEMBL8327489 | 0.85 | LMNA (0.43) | MTNR1AMTNR1BABCB1HTR1ADRD2 | |
| SCHEMBL8324057 | 0.82 | PTGER4 (0.59) | MTNR1AMTNR1BABCB1HTR1ADRD2 | |
| SCHEMBL11557673 | 0.81 | KDM4E (0.60) | MTNR1AMTNR1BAPPMAOB | |
| SCHEMBL8406718 | 0.80 | ABCB1 (0.63) | MTNR1AMTNR1BABCB1HTR1ADRD2 | |
| SCHEMBL6258777 | 0.79 | HSP90AA1 (0.50) | TSHR | |
| SCHEMBL8325289 | 0.79 | ABCB1 (0.62) | MTNR1AMTNR1BABCB1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |