Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324057 | 0.93 | PTGER4 (0.59) | ABCB1HTR1ADRD2ABCG2LMNA | |
| SCHEMBL8321603 | 0.89 | PTGER1 (0.54) | ABCB1HTR1ADRD2ABCG2LMNA | |
| SCHEMBL8325289 | 0.88 | ABCB1 (0.62) | ABCB1HTR1ADRD2ABCG2LMNA | |
| SCHEMBL8322935 | 0.88 | CCR5 (0.49) | LMNAHPGDPTGER1 | |
| SCHEMBL8324955 | 0.88 | MTNR1A (0.59) | ABCB1HTR1ADRD2MAOB | |
| SCHEMBL8318934 | 0.88 | HTR1A (0.60) | ABCB1HTR1ADRD2ABCG2PTGER1 | |
| SCHEMBL6258777 | 0.86 | HSP90AA1 (0.50) | LMNAHPGD | |
| SCHEMBL8327489 | 0.85 | LMNA (0.43) | ABCB1HTR1ADRD2ABCG2LMNA | |
| SCHEMBL8409730 | 0.83 | HTR1A (0.60) | ABCB1HTR1ADRD2ABCG2PTGER1 | |
| SCHEMBL8322308 | 0.82 | PTGER4 (0.59) | ABCB1HTR1ADRD2ABCG2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |