Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327356 | 0.72 | GAA (0.38) | SMN1; SMN2LMNATP53CASP1CASP7 | |
| SCHEMBL8331002 | 0.71 | GAA (0.43) | SMN1; SMN2LMNACCR2GAAFEN1 | |
| SCHEMBL8327401 | 0.71 | GAA (0.39) | SMN1; SMN2LMNATP53CASP1CASP7 | |
| SCHEMBL8324966 | 0.69 | CACNA1G (0.39) | SMN1; SMN2LMNATP53CASP1CASP7 | |
| SCHEMBL8327247 | 0.68 | PARP1 (0.46) | SMN1; SMN2PARP1GAAFEN1ALDH1A1 | |
| SCHEMBL8328463 | 0.67 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNACCR2GAAFEN1 | |
| SCHEMBL8712895 | 0.66 | FEN1 (0.41) | SMN1; SMN2HTR6GAAFEN1ALDH1A1 | |
| SCHEMBL8329409 | 0.65 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPARP1GAAALDH1A1 | |
| SCHEMBL9548389 | 0.63 | ALDH1A1 (0.38) | SMN1; SMN2LMNAGAAALDH1A1TDP1 | |
| SCHEMBL6945407 | 0.59 | LMNA (0.45) | SMN1; SMN2LMNAPARP1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |