Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.43 |
| ▸ | EDNRA | P25101 | 14/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27535738 | 0.88 | EDNRB (0.41) | EDNRBEDNRAEP300HIF1APIK3CA | |
| SCHEMBL8326904 | 0.86 | EDNRA (0.48) | EDNRBEDNRA | |
| SCHEMBL8322432 | 0.83 | LMNA (0.41) | EDNRARORC | |
| SCHEMBL7013707 | 0.82 | EDNRA (0.45) | EDNRARORCPIK3CAMTOR | |
| SCHEMBL7292782 | 0.81 | EDNRA (0.40) | EDNRARORC | |
| SCHEMBL7013473 | 0.81 | EDNRA (0.44) | EDNRARORCPIK3CAMTOR | |
| SCHEMBL7012433 | 0.81 | EDNRA (0.47) | EDNRBEDNRARORCPIK3CAMTOR | |
| SCHEMBL7326664 | 0.81 | DHPS (0.42) | EDNRARORC | |
| SCHEMBL7009897 | 0.80 | EDNRA (0.43) | EDNRARORCEP300HIF1APIK3CA | |
| SCHEMBL7296309 | 0.80 | EDNRA (0.39) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |