Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IRS1 | P35568 | 1/20 | 0.47 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480182 | 1.00 | KDM4E (0.48) | KDM4EMAPTMEN1NPC1KMT2A | |
| SCHEMBL13201316 | 0.90 | KDM4E (0.45) | KDM4EMAPTMEN1NPC1KMT2A | |
| SCHEMBL13201305 | 0.77 | MMP8 (0.60) | MAPTNPC1KMT2APOLBALDH1A1 | |
| SCHEMBL8325154 | 0.74 | ALDH1A1 (0.42) | NPC1POLBALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL8321476 | 0.73 | F10 (0.39) | KDM4EMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL13201304 | 0.73 | POLB (0.54) | KDM4EMEN1NPC1KMT2APOLB | |
| SCHEMBL2953994 | 0.70 | ACHE (0.54) | KDM4EMEN1NPC1KMT2APOLB | |
| SCHEMBL14057261 | 0.69 | KDM4E (0.44) | KDM4EMAPTMEN1NPC1KMT2A | |
| SCHEMBL8320723 | 0.68 | PSEN1 (0.43) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL2964063 | 0.68 | PSEN1 (0.43) | MEN1KMT2APOLBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |