Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LOX | P28300 | 3/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201305 | 0.82 | MMP8 (0.60) | ALDH1A1MMP8MMP12MMP13POLB | |
| SCHEMBL7971275 | 0.81 | ACHE (0.48) | ALDH1A1ATMLMNATDP1HTT | |
| SCHEMBL13201304 | 0.79 | POLB (0.54) | ALDH1A1POLBLMNATDP1HTT | |
| SCHEMBL8319435 | 0.77 | MMP2 (0.48) | ALDH1A1MMP8MMP12ATMLMNA | |
| SCHEMBL13201290 | 0.75 | AKR1C3 (0.56) | ALDH1A1LMNATDP1L3MBTL1TSHR | |
| SCHEMBL8327363 | 0.75 | MMP2 (0.48) | ALDH1A1MMP8MMP12TDP1L3MBTL1 | |
| SCHEMBL13480182 | 0.74 | KDM4E (0.48) | ALDH1A1MMP8MMP12MMP13POLB | |
| SCHEMBL8325166 | 0.74 | KDM4E (0.48) | ALDH1A1MMP8MMP12MMP13POLB | |
| SCHEMBL8320725 | 0.73 | EPHX2 (0.42) | ALDH1A1ATMLMNATDP1HTT | |
| SCHEMBL2964063 | 0.73 | PSEN1 (0.43) | ALDH1A1MMP12POLBATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1585728-B1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-02-24 | — | — | EP | disclosed |