Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319376 | 0.87 | EPHX2 (0.48) | POLBRAB9AHPGDNPC1EPHX2 | |
| SCHEMBL13201305 | 0.79 | MMP8 (0.60) | POLBRAB9AHPGDNPC1EPHX2 | |
| SCHEMBL8325154 | 0.79 | ALDH1A1 (0.42) | POLBNPC1ALDH1A1TSHRLMNA | |
| SCHEMBL7971275 | 0.78 | ACHE (0.48) | NPC1EPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL8319435 | 0.76 | MMP2 (0.48) | ALDH1A1TSHRLMNAHTTSMN1; SMN2 | |
| SCHEMBL3719656 | 0.75 | POLB (0.61) | POLBRAB9AALDH1A1TDP1 | |
| SCHEMBL8320725 | 0.74 | EPHX2 (0.42) | EPHX2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL8320723 | 0.74 | PSEN1 (0.43) | POLBEPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL2964063 | 0.74 | PSEN1 (0.43) | POLBEPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL2969395 | 0.74 | TDP1 (0.41) | POLBMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |