Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318730 | 0.91 | TBXAS1 (0.60) | TBXAS1KDM4AKDM4CCYP2E1CYP3A4 | |
| SCHEMBL8326744 | 0.90 | HDAC1 (0.56) | HDAC4HDAC1HDAC8HDAC6CYP2E1 | |
| SCHEMBL8325813 | 0.82 | TBXAS1 (0.56) | HDAC4HDAC1HDAC8HDAC6TBXAS1 | |
| SCHEMBL8319688 | 0.82 | TBXAS1 (0.46) | HDAC1HDAC8HDAC6TBXAS1KDM4A | |
| SCHEMBL1165168 | 0.81 | HDAC1 (0.61) | HDAC4MEF2DHDAC1HDAC8HDAC6 | |
| SCHEMBL1165170 | 0.81 | HDAC1 (0.61) | HDAC4MEF2DHDAC1HDAC8HDAC6 | |
| SCHEMBL8318908 | 0.80 | KDM4A (0.40) | HDAC4MEF2DHDAC1HDAC8HDAC6 | |
| SCHEMBL8322937 | 0.78 | CYP3A4 (0.49) | HDAC1HDAC8TBXAS1KDM4AKDM4C | |
| SCHEMBL13762662 | 0.75 | HDAC4 (0.71) | HDAC4MEF2DHDAC1HDAC8HDAC6 | |
| SCHEMBL13762664 | 0.75 | HDAC4 (0.71) | HDAC4MEF2DHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |