Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328799 | 0.86 | ATM (0.41) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8328861 | 0.79 | L3MBTL1 (0.46) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3150589 | 0.69 | ATM (0.45) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8328348 | 0.69 | ATM (0.45) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9430376 | 0.68 | HTT (0.46) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL21239633 | 0.68 | KDM4E (0.58) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8326257 | 0.67 | KDM4E (0.42) | ATML3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL8658440 | 0.66 | KDM4E (0.40) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL9429930 | 0.66 | HTT (0.44) | ATMHTTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL344255 | 0.66 | L3MBTL1 (0.59) | ATMHTTL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |