Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | DHODH | Q02127 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8687997 | 0.95 | KDM4E (0.64) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL10948402 | 0.87 | KDM4E (0.77) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL8327199 | 0.84 | KDM4E (0.74) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL8690724 | 0.83 | SLC6A3 (0.53) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL12237495 | 0.81 | KDM4E (0.50) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL8321360 | 0.81 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10DHODHHPGD | |
| SCHEMBL19508777 | 0.79 | TACR3 (0.65) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL13919575 | 0.78 | ALDH1A1 (0.52) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL19508615 | 0.78 | PLA2G2A (0.65) | KDM4EMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL28131200 | 0.77 | L3MBTL1 (0.50) | KDM4EMAPK1TDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709377-B1 | Process for producing quinolin-2-yl benzoic acid compounds | ASAHI GLASS CO LTD (JP) | 1999-09-29 | — | — | EP | disclosed |
| EP-0693478-B1 | Quinoline compounds | GREEN CROSS CORP (JP) | 1998-08-12 | — | — | EP | disclosed |
| US-5780634-A | Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds | THE GREEN CROSS CORPORATION (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5665881-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ANGIOTENSIN II ANTAGONIST | THE GREEN CROSS CORPORATION (JP) | 1997-09-09 | — | — | US | disclosed |
| EP-0569013-B1 | Quinoline compounds as angiotensin II antagonists | GREEN CROSS CORP (JP) | 1996-08-28 | — | — | EP | disclosed |
| EP-0709377-A1 | Process for producing quinolin-2-yl benzoic acid compounds | ASAHI GLASS COMPANY LTD. (JP) | 1996-05-01 | — | — | EP | disclosed |
| EP-0693478-A1 | Quinoline compounds | THE GREEN CROSS CORPORATION (JP) | 1996-01-24 | — | — | EP | disclosed |
| US-5478832-A | Angiotensin II antagonists; cardiovascular disorders | THE GREEN CROSS CORPORATION (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0569013-A1 | Quinoline compounds as angiotensin II antagonists | THE GREEN CROSS CORPORATION (JP) | 1993-11-10 | — | — | EP | disclosed |