SCHEMBL8326756

SCHEMBL8326756

COCCN(CCCN1C(=O)c2ccccc2C1=O)Cc1ccc(F)cc1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAOB P27338 15/20 0.59
ACHE P22303 9/20 0.55
BCHE P06276 6/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8131752 0.79 MAOB (0.83) MAOBACHEBCHE
SCHEMBL9824940 0.77 MAOB (0.83) MAOBACHEBCHE
SCHEMBL7130995 0.76 MAOB (0.64) MAOBACHEBCHE
SCHEMBL2249163 0.76 MAOB (0.63) MAOBACHE
SCHEMBL8398570 0.76 MAOB (0.84) MAOBACHEBCHE
SCHEMBL21084263 0.75 MAOB (1.00) MAOBACHEBCHE
SCHEMBL8327446 0.74 MEN1 (0.43)
SCHEMBL8328677 0.74 MEN1 (0.43)
SCHEMBL8329022 0.73 ALDH1A1 (0.50) MAOBACHEBCHE
SCHEMBL10719302 0.73 RAB9A (0.67)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0760368-B1 PYRIMIDINE DERIVATIVES NISSHIN FLOUR MILLING CO (JP) 1999-07-28 EP disclosed
US-5736550-A TREATMENT OF GASTROINTESTINAL TRACT DISORDERS NISSHIN FLOUR MILLING CO., LTD. (JP) 1998-04-07 US disclosed
EP-0760368-A1 NOVEL PYRIMIDINE DERIVATIVE NISSHIN FLOUR MILLING CO., LTD. (JP) 1997-03-05 EP disclosed