Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11005384 | 0.84 | CYP1A2 (0.42) | BCHEMETAP2TSHRMEN1KMT2A | |
| SCHEMBL8331541 | 0.81 | SIGMAR1 (0.38) | METAP2SIGMAR1MEN1KMT2ATHRB | |
| SCHEMBL8329421 | 0.81 | METAP2 (0.40) | METAP2MEN1KMT2ATHRBATM | |
| SCHEMBL8328919 | 0.81 | EPHX1 (0.46) | METAP2TSHRMEN1KMT2A | |
| SCHEMBL8332090 | 0.81 | METAP2 (0.38) | BCHEMETAP2TSHRSIGMAR1MEN1 | |
| SCHEMBL8331369 | 0.80 | MEN1 (0.36) | METAP2TSHRMEN1KMT2ATHRB | |
| SCHEMBL8328587 | 0.80 | EPHX1 (0.33) | METAP2TSHRMEN1KMT2A | |
| SCHEMBL5413788 | 0.76 | KDM4E (0.38) | METAP2MEN1KMT2ATHRBATM | |
| SCHEMBL8329946 | 0.76 | EPHX1 (0.49) | METAP2TSHRMEN1KMT2A | |
| SCHEMBL8328592 | 0.76 | NFKB1 (0.34) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |