Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675628 | 0.91 | PTGER1 (0.48) | PTGER1SLC6A9PTGER4PTGER3PTGER2 | |
| SCHEMBL8324992 | 0.85 | CCR5 (0.48) | PTGER1LMNAHPGDSMPD1HDAC1 | |
| SCHEMBL8325607 | 0.85 | PTGER1 (0.52) | PTGER1LMNAHPGDMAPTKMT2A | |
| SCHEMBL8327306 | 0.83 | GCK (0.53) | PTGER1LMNAHPGDMTNR1BSMPD1 | |
| SCHEMBL8166853 | 0.79 | STAT3 (0.57) | PTGER1LMNAHPGDMAPTKMT2A | |
| SCHEMBL8323253 | 0.79 | PTGER4 (0.59) | PTGER1LMNAHPGDMTNR1BMTNR1A | |
| SCHEMBL8678933 | 0.79 | PTGER1 (0.42) | PTGER1LMNAHPGDMTNR1BSMPD1 | |
| SCHEMBL8327489 | 0.78 | LMNA (0.43) | PTGER1LMNAHPGDMTNR1BMTNR1A | |
| SCHEMBL8409906 | 0.77 | CCR6 (0.44) | PTGER1LMNASMPD1HDAC1HDAC8 | |
| SCHEMBL8408175 | 0.77 | HPGD (0.56) | PTGER1LMNAHPGDMTNR1BSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |